Flex Equine Plus

Vetpro 3 Horses Flex-Equine Plus is a nutriceutical (100% natural) supplement formulated for feeding to horses with impaired joint function. It helps to maintain cartilage elasticity and aids in the repair of damaged cartilage. It is an improved development of Flex Equine as it also contains Undenatured Collagen Type ll, which has been scientifically proven to increase the already established benefits of our formula with Glucosamine, mixed Glycosaminoglycans (Chondroitin), Manganese Ascorbate, Copper Chelate, Zinc Chelate and Gelatin.

Joint Soreness – Trauma or Age?
In fact it can develop from trauma, direct or from the concussive effects of the legs striking on hard surfaces, or from age i.e. degenerative loss of cartilage quality. The resulting osteoarthritis is similar in humans and horses. Joint pain can affect horses of all ages as confirmation defects, work on hard or uneven surfaces can be detrimental at any age. While anti-inflammatory drugs can relieve pain and reduce inflammation, it has been scientifically proven that drug free Nutriceuticals containing key ingredients at the right levels can in fact assist cartilage quality and so help relieve the prevalent condition.

The role of the Actives: Glucosamine – Chondroitin – Coolagen Type II – Gelatin – Zinc and Copper
Glucosamine is the major structural component of the principle Glycosaminoglycan (GAG) in cartilage. It is the GAGs that maintain the high water content of cartilage and hence its ability to resist the compressive forces during weight bearing. When the joints need more Glucosamine, as suggestive age or working damage, resulting finally in degenerative joint disease, the body is unable to speed up production because it is set at a fixed rate, therefore a supplementary form of Glucosamine is beneficial. Scientific studies have shown that 10-12,000 mg daily is required for effective repair, and that the body is able to absorb the Glucosamine and use it directly in the joints to repair and maintain the cartilage.

The mixed Glycosaminoglycans (GAGS) include Chondroitin Sulphate and Keratin Sulphate. Both these are used in the cartilage repair process. The Manganese Ascorbate is necessary for the conversion of the Glucosamine to GAGs to occur. Note Glucosamine alone is not effective – it needs to be in a formulation that ensures the required dose is not absorbed by the liver, but reaches the cartilage. Science has also shown that the combination of Glucosamine and Chondroitin provides a more effective response than either actives alone.

Undenatured Collagen Type ll is a new discovery that was determined to be effective in relieving osteoarthritis in humans but has now been independently scientifically tested on horses and showed remarkable positive responses. Flex Equine Plus contains 555mg – higher than the 450mg shown to be effective in the science trials.

Copper and Zinc are important trace elements that are essential for cartilage repair and maintenance. 3 Horses Flex-Equine Plus uses these minerals in the latest chelated form (glycinated) which means they are absorbed quickly and efficiently from the gut.

The gelatin in the formula includes high levels of Glycine and Proline, both of which are important components of collagen, the protein found in the cartilage matrix and again science has shown that gelatin improves the homeostasis of those amino acids required for cartilage synthesis.

Vetpro Flex Equine Plus contains the recommended amounts of the actives to be effective in improving joint elasticity and joint repairs. It puts the spring back into the horse and can assist to prolong the competitive life of the horse.

Read more about joint damage, deterioration, arthritis and DJD here…

Active Ingredients Per 30 gm dose:
Glucosamine Sulphate 12g
Undenatured Type ll Collagen 555mg
Mixed Glycosaminoglycans 1.8gm
Manganese Ascorbate 3.6mg
Copper Chelate 13.4mg
Zinc Chelate 25.9mg
Gelatin 15.2gm

Loading Dose (first 4-6 weeks)/ Maintenance Dose:
Horses (450-500kg) 26-30gm/ Horses 13-15gm
Ponies (225-350kg) 13-20gm/ Ponies 7.5-10gm

The Science:
Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses.

Gupta RC, Canerdy TD, Skaggs P, Stocker A, Zyrkowski G, Burke R, Wegford K, Goad JT, Rohde K, Barnett D, DeWees W, Bagchi M, Bagchi D.

Relation of collagen synthesis to chondroitin sulfate synthesis in cartilage Bohumila Rokosová-Čmuchalová, J. Peter Bentley

The Effect of Glucosamine and Chondroitin on Stressed Equine Cartilage Explants. R.S.A Harlan MS, R.C.A Haut PhD, M.W.A. Orth PhD
Effects of Chondroitin and Glucosamine Sulfate in a Dietary Bar Formulation on Inflammation,0 Interleukin-1CEB2, Matrix Metalloprotease-9, and Cartilage Damage in Arthritis. M. Chou*,Nathalie Vergnolle ,Jason 0 J. McDougall,John L. Wallace,Stephanie Marty,Val Teskey and AndreG. Buret.
Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism. Dechant JE, Baxter GM, Frisbie DD, Trotter GW, McIlwraith CW

Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone Homandberg GA, Guo D, Ray LM, Ding L

Effects of Oral Glucosamine and Chondroitin Sulfates Supplementation on Frequency of

Intra-articular Therapy of the Horse Tarsus Martha R. Rodgers, VMD

Role of glucosamine in the treatment for osteoarthritis

Jean-Yves Reginster • Audrey Neuprez •Marie-Paule Lecart • Nathalie Sarlet •Olivier Bruyere

Study of gelatin supplemented diet on amino acid homeostasis in the horse. M. Coenen, K. Appelt, A. Niemeyer,I. Vervuert

EFSA Journal 2010;8(10):1808 Scientific Opinion on the substantiation of health claims related to manganese contribution to normal formation of connective tissue (ID 404) Contribution to normal formation of connective tissue

Studies on the Role of Manganese in Bone Formation R. M. Leach, JR. Andanna-marie Muenster

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